Targeted weight reduction using Sibutramine

Stritecka Hana, Hlubik Pavel, Hlubik Jan

University of Defence, Faculty of Military Health Science, Department of Military Hygiene, Group of Nutrition Hygiene, Trebeska 1575, 500 01 Hradec Kralove, Czech Republic.
Faculty of Electrical Engineering CTU, Karlovo namesti 13, 121 35 Praha 2, Czech Republic.

Obesity is a serious chronic disease resulting from positive energy balance. Obesity is also an independent risk factor for the development of non-communicable widespread disorders. The endpoint of the trial was a targeted reduction of excessive body weight in 99 individuals with BMI over 30 or 27 kg/m2 respectively. Three-month weight reduction therapy was based on the restriction of energy intake and pharmacotherapy by Sibutramine hydrochloride monohydrate (Sibutramine) 10mg/person/day. Results: Three-month targeted therapy resulted in statistically significant decrease of BMI, body weight, body fat and waist circumference. The reduction improved lipid profile and resulted in the decrease of systolic and diastolic blood pressure. Heart rate increased only insignificantly. Targeted reduction of excessive body weight using Sibutramine pharmacotherapy had a positive effect on anthropometric and biochemical characteristics without any adverse effect of nutrition in participating individuals.

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